Here the author interview on the Brain Science Podcast, episode 31, at http://brainsciencepodcast.com

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Product Description

Studies of mechanisms in the brain that allow complicated things to happen in a coordinated fashion have produced some of the most spectacular discoveries in neuroscience. This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. It takes a fresh look at the co-evolution of structure and function in the mammalian brain, illustrating how self-emerged oscillatory timing is the brains fundamental organizer of neuronal information. The small world-like connectivity of the cerebral cortex allows for global computation on multiple spatial and temporal scales. The perpetual interactions among the multiple network oscillators keep cortical systems in a highly sensitive metastable state and provide energy-efficient synchronizing mechanisms via weak links.
In a sequence of cycles, Gyorgy Buzsaki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing accessible to any reader with some scientific knowledge is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.

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Product Details

• Amazon Sales Rank: #26501 in Books
• Published on: 2006-08-03
• Original language: English
• Number of items: 1
• Binding: Hardcover
• 464 pages

Review

"Gyorgy Buzsaki's Rhythms of the Brain is an excellent compendium on the rapidly expanding research into the mechanisms and functions of neuronal synchronization. Buzsaki presents such synchronization as a binding glue that integrates many levels of neuroscientific investigation with one another and with neighboring disciplines...Buzsaki manages to elegantly integrate insights from physics, engineering, and cognitive psychology with contributions from cellular, systems, cognitive, and theoretical neuroscience."--Science
"This is definitely an intriguing book that provides a comprehensive review of current knowledge on brain rhythms...this book is worth the time."--Doody's
"In Rhythms of the Brain, Gyorgy Buzsaki does a remarkable job of summarizing a vast body of literature on the topic...The book is a 'must read' for anyone interested in understanding the functioning of large and complex brain circuits."--Nature
"What makes this book so valuable is its range; Buzsaki has a worldly intellect, open to information from any discipline that provides insight, while insisting on a rigorous distinction between fact and baloney...Perhaps the greatest value of Rhythms of the Brain is that it provides a starting point for students and scientists who see the importance of this field and want to get a solid overview."--Nature Neuroscience
"In this entertaining monograph the author addresses issues related to the genesis of brain rhythms and their contribution to the "invisible operations of the brain"...one of the most thought-provoking and fun books in neuroscience that I have read in some time."--Mathematical Reviews
"Highly original exposition of a broad swathe of modern neuroscience. Indeed, it brings together so many apparently disparate strands, and levels on the reductionistic scale, that it deserves a must read score, especially for neuroscientists looking to get an up-to-date and challenging exposition of many of the big questions, even if they are not fundamentally interested in oscillations per se...If sharp wave ripples, associated with consummatory behavior in rodents, have the same connotations in humans, they too will likely occur in the readers brain as a reward for the attention this book deserves."--Neuron
"The book is beautifully written...This book is seriously recommended for those who truly wonder about the brain and its function."--Neuroscience

About the Author

Gyorgy Buzsaki is a Board of Governors Professor of Neuroscience at Rutgers University. His primary research interests are in brain oscillations, sleep and memory, and with more than 200 papers published on these topics, he is among the top 250 most-cited neuroscientists. Dr. Buzsaki is a Fellow of the American Association for the Advancement of Science and honorary member of the Hungarian Academy of Sciences, and he sits on the editorial boards of several leading neuroscience journals.

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Customer Reviews

A dense but readable explanation of the temporal aspects of neural processing
A good popular science book will provide laypeople with an exciting perspective on the state of the art in a particular field. But this comes at a price: typically such books are written from just a single theoretical perspective, glazing over or altogether ignoring details that might be considered controversial within the academic community. To understand these deeper issues, an interested layperson would have to trudge through academic textbooks, or for the most cutting-edge topics, delve into the often impenetrable peer-reviewed literature.

And then there are the absolute best popular science books. György Buzsáki's "Rhythms of the Brain" is of this latter variety. Not only does it provide a wide-ranging and readable introduction to neural oscillators, but every crucial argument is carefully footnoted with deeper explanations, some qualifications, and suggestions for additional reading.

"Rhythms of the Brain" begins with the premise that "structure defines function," and then outlines how the architectural principles of neural networks can give rise to neural oscillations. In the process, he meticulously covers topics like the complex, small-world, scale-free connectivity of cortex without resorting to complicated equations - the concepts are carefully grounded in real-world analogies and lay terms.

Buzsáki introduces several other topics that are usually found only in mathematically sophisticated academic works on the brain: for example, how "neural noise" can actually enhance processing through stochastic resonance and the 1/f or "pink noise" signature of EEG, mechanisms of "phase precession" and "phase reset" within nested oscillations, and the difference between relaxation and harmonic oscillators.

It is perhaps not surprising that Buzsáki is the author of such a book - holding both an MD and a Neuroscience PhD, Buzsáki's has published over 185 peer-reviewed publications, 10 book chapters, and 2 edited volumes spanning the last 35 years. His lab at Rutgers consists of a veritable army of researchers, including 8 post-docs and 4 grad students.

After reading "Rhythms of the Brain," it's easy to understand why there's so much demand for working in this laboratory. There's potentially an entirely new field of neuroscience lurking in here: Buzsáki discusses distinct oscillations with frequencies spanning 4 orders of magnitude, from the ultra-slow ("slow 4": .02 Hz) to the ultra-fast ("high gamma": 600 Hz) and everything in between.

Although this book is probably not suitable for entry-level laypeople (a good popular science introduction to the brain and its rhythms is "I of the Vortex"), it is virtually guaranteed to please everyone with some previous neuroscience experience, literary or empirical. Beware also that "Rhythms of the Brain" is quite dense (with the copious footnotes constituting almost an entire second volume!) and is therefore more likely to be enjoyed with caffeine than as a relaxing bedside book.

Some may criticize "Rhythms of the Brain" for failing to offer a comprehensive "big picture" summary of how each of these oscillations contribute to cognition (although hints are there, to be sure). For me, this is actually a strength of the book; half-informed conjecture and hasty extrapolation ruins far too many popular "science" books on the brain, and they become prematurely outdated. Besides, such speculation is far more fun to do as a reader - and for this Buzsáki has provided fertile ground.

The Brain: It's All Cycles and Rhythms
György Buzsáki's new book is superb.

One of the problems for people trying to understand some of the spectacular advances in science and medicine is that much of it has become not just complex, but highly specialized, with each discipline developing its own vocabulary. Many books are written for the cognoscenti and many others by professional writers trying to explain science in lay language. There are relatively few scientists working at the cutting edges of their fields who want - or in some cases are able - to communicate their findings to a broad audience.

This book is by an internationally recognized expert, a Professor at Rutgers who is amongst the 250 most cited neuroscientists in the world. He is passionate about his topic, literate, patient and humble. In this book he takes a complex topic - the dynamic function of the brain - and unlocks not just the secrets that he and others have uncovered, but you have the chance to look over his shoulder and understand why he has reached certain conclusions, while exposing some of the human side of the scientific enterprise. It is not all objectivity and cooperation, there is also the politics, bickering and suppression and omission of data that does not fit a pet model or theory.

As the title suggests, György Buzsáki's particular field of interest is brain oscillations: it has an extraordinary capacity for generating waves that organize its activity. We have known for centuries that there are cycles that control the rhythms of our hearts, lungs, metabolism and endocrine systems. But in recent years we have begun to suspect that the brain's constantly active rhythms, including its cycles of electrical activity, are essential to its "deepest and most general functions." That in itself is fascinating, but this is a very personal book.

He begins by saying, "The short punch line of this book is that brains are foretelling devices and their predictive powers emerge from the various rhythms they perpetually generate." A little later he explains the what, when, where, how and who of his first awakening to the importance of this realization. He says that it came, "in April, 1970, during a physiology lecture given by Endre Grastyán in the beautiful town of Pécs, on the sunny slopes of the Mecsek mountains in Hungry."

As you will see, this is no ordinary account of brain function.

It is divided into thirteen "Cycles:"
Cycle 1. Introduction.
Cycle 2. Structure defines function.
Cycle 3. Diversity of cortical functions is provided by inhibition.
Cycle 4. Windows on the brain.
Cycle 5. A system of rhythms: from simple to complex dynamics.
Cycle 6. Synchronization by oscillation.
Cycle 7. The brain's default state: self-organized oscillations in rest and sleep.
Cycle 8. Perturbation of the default patterns by experience.
Cycle 9. The gamma buzz: gluing by oscillations in the waking brain.
Cycle 10. Perceptions and actions are brain state-dependent.
Cycle 11. Oscillations in the "other cortex:" navigation in real and memory space.
Cycle 12. Coupling of systems by oscillations.
Cycle 13. The tough problem.
References.

The book is well written and scholarly. But this is not the scholarship of the show off: he is a natural scholar who is interested in knowledge for its own sake and for the ways in which it can illuminate his points. He wants to be understood beyond the narrow confines of the academy. He also understands the value of cross-pollination: how findings and insights garnered in one part of science, medicine, engineering and even art, can inform his work in the brain.

The book is full of fascinating insights. He discusses the way in which the brain is a complex adaptive, self-organizing system, while the neuron-rich cerebellum is so highly efficient and so localized that it can probably not give rise to conscious experience.

Most of us will have some points of disagreement. He is, perhaps, too certain that anatomy is destiny: that we are the cycles and oscillations created by our brains. Not all of the evidence is quite so cut and dried. But it is also certain from Buzsáki's writing that he would relish the chance to debate his points.

This is a fascinating book that may in places be a little demanding for the non-scientist. But it is also a very human story that lets the readers inside the head and the laboratory of a world-class scientist and storyteller.

Highly recommended.

Timing neuronal activity
"Rhythms of the Brain"
by Professor György Buzsáki,
(member of the Hungarian Academy of Sciences)

There are many windows to the brain, many approaches to probe its secrets. However, a very few of them allow an in depth understanding of the most complex computational mechanisms which underlie our cognitive abilities. The approach chosen by Professor György Buzsáki in his latest book "Rhythms of the Brain" is to investigate the role of timing in governing neuronal activity. The choice is exceptionally fruitful, and sheds much new light on the emergent properties and collective behaviour of neuronal ensembles. The book is presently the most authoritative introduction to this very complex field of brain research.
In brief, the book tells that "brains are foretelling devices, and their predictive powers emerge from the various rhythms they perpetually generate". This briefing sets out the two main lines of thought recurring in "cycles" instead of chapters in the book. For the one it tells that instead of simply reacting to various kinds of input, the output of our brain is able to control its input. For the other, to do this, the brain is continuously engaged in generating various kinds of rhythmic activities, which can chunk the time and group neuronal activity into meaningful collective behaviours.
The book is outstanding in several respects. Buzsáki managed to find the fragile balance in styles and detail to be digestible to the lay person and to remain exciting to the super-specialist. Thanks to the nowadays all too rare single authorship, the line of thoughts are unbroken, and the chapters are linked together by a logic arching over the entire book. Buzsáki is leading us through various disciplines with impressive accuracy. Due to the nature of the topic, beside the numerous branches of electrophysiology (from single cell intracellular activity to MEG), the tightly linked neuroanatomy, physics, mathematics and even psychology and philosophy are lined up to bring us closer to understanding the generation of rhythmic events and their functional roles in the brain. The book is a must on the shelf of not only neuroscientist, but also of all those interested in the basic laws of our brain. The thoughts the book generates will certainly oscillate and reverberate in our mind conducted by the "rhythms of the brain".