Product Description

Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer?s disease. AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators.

Product Details

• Amazon Sales Rank: #231702 in eBooks
• Published on: 2004-01-22
• Format: Kindle Book
• Number of items: 1

Customer Reviews

Excellent Book
Arachidonate Remodeling and Inflammation, edited by Alfred Fonteh and Robert Wykle provides an excellent, up-to-date review of the control of cellular arachidonic acid. The editors did a wonderful job of obtaining contributors to this book who are all highly respected investigators in this field of research. This book is an excellent resource for scientists who are actively involved in research dealing with the control of cellular arachidonate, as well as those who have a more peripheral interest in the field. Importantly, this book is the first volume to fully review the important and emerging area of arachidonate remodelling and its potential role in multiple disease processes. As an active academic researcher in the field of arachidonaic acid metabolism, I highly recommend this book.