Product Description

To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you'll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski's Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. And, as an Expert Consult title, this thoroughly updated 7th edition comes with access to the complete contents online, fully searchable.

• Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases.

• Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management.
  
• Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance.
  
• Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need.
  
• Provides access to the complete contents online, fully searchable, enabling you to consult it rapidly from any computer with an Internet connection.

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

---

Product Details

• Amazon Sales Rank: #381707 in Books
• Published on: 2008-12-03
• Original language: English
• Number of items: 1
• Binding: Hardcover
• 1872 pages

From The New England Journal of Medicine
The fifth edition of Nathan and Oski's Hematology of Infancy and Childhood lives up to its reputation as the bible of pediatric hematology. There simply is no other book that approaches either the breadth or the depth of content for the specialist in pediatric hematology.

Pediatric hematology has been for years a focus of human genetics and molecular medicine, in part because of the accessibility of samples of blood and bone marrow for study. The discovery of the amino acid substitution that causes sickle hemoglobin established the first scientific basis for understanding the molecular nature of a genetic disease. The promise of molecular medicine has begun to bear fruit in the usefulness of molecular diagnostics in pediatric hematologic disorders and in the clinical benefits of recombinant molecules such as erythropoietin and granulocyte colony-stimulating factor. The book is based on the principle that critically presented scientific data establish the foundation of clinical practice. Hence, basic and clinical research is emphasized rather more than medical practice. Progress in the molecular understanding of hematologic disease is presented in depth in chapters on the red-cell membrane and enzymes, phagocytes, the immune system, and cancer. Several of the chapters are written to provide background information and perspective for students and practitioners of wet-bench research who will, as stated in the preface, "continue the great progress recorded here." The 75-page chapter on normal hematopoiesis by Sieff, Nathan, and Clark is a critical, analytical review written in a conversational style. Following Nathan's editorial principle of expanding the state-of-the-art presentation of "hot" areas of research and contracting those topics with little recent research activity, the hematopoiesis chapter contains a wonderful summary of the current knowledge of hematopoietic growth factors and their receptors and includes data from knockout mice, extensive descriptions of pertinent transcription factors, and a large section on hematopoietic-cell signal-transduction pathways. The authors are careful to put this vast amount of information, much of it obtained in the past five years, in the perspective of all that we do not yet understand.

Frank Oski, chairman of Pediatrics at Johns Hopkins, died recently and is sorely missed by all in the field. However, his contributions to previous editions live on, especially in the succinct chapter "A Diagnostic Approach to the Anemic Patient," which is of great educational value at all levels of clinical training. Oski's original chapter on neonatal red-cell disorders, updated with more recent data on, for example, cord-blood hematologic values, anemia due to blood drawing, and methemeglobinemia in neonates treated with nitric oxide, remains a classic that simply cannot be equaled elsewhere. A new editor, Stuart Orkin, has successfully revised the section on hemostasis, expanding it from five chapters to eight, including a chapter dedicated to bleeding patients that will be helpful to many clinicians.

This textbook will undoubtedly be useful to many others not directly involved in clinical or research pediatric hematology. First, it provides basic scientists with a clinical perspective. Second, pediatric and adult subspecialists will occasionally need it to read about rare conditions, and it should be included in the reference collection of every library on adult hematology or general pediatrics. However, its usefulness for the general pediatrician or pediatric surgeon is debatable, because considerably more scientific background is presented than the generalist will have time to review. To expand clinical utility without losing their fundamental scientific approach, the editors might consider for the next edition a multilayered approach that adds more detailed presentations of current medical practice in distinctively identified sections within each chapter.

There have been major revisions since the last edition five years ago, reflecting the relative importance of new and old areas of research more than the clinical utility of the information presented. The chapters not revamped have been carefully updated. The only text unaltered from previous editions is the classic history of pediatric hematology written years ago by the late Wolf Zuelzer. David Nathan has appended to it a sorely needed but very brief historical perspective on more recent developments. In the next edition, I hope that Nathan will give us the recent history of the intertwined progress of pediatric hematology and molecular medicine.

Reviewed by Christopher N. Frantz, M.D.
Copyright © 1998 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.

Review
"This is an excellent text of non-malignant paediatric haematology, carrying on the well established tradition of previous editions... The book is underpinned by inclusion of up-to-date information about the pathogenesis of haematological diseases, which is especially important given the huge contribution of molecular geneticists to the understanding of paediatric haematology, and vice versa."
BMA Book Awards 2009 - judges comments

---

Customer Reviews

5 stars since it's the heme book for peds.
Not practical for general pediatrics or clinical hematology. More molecular and cellular than i thought it would be. For attendings, libraries, depts. Don't read unless you're going to do a presentation to a bunch of MD PhD's or something like that.

hematology of infancy and childhood- Nathan & Oski
the book is a classic tecnical hematology textbook for hematologists and pediatrics and in the new edition, with the on line access , it's been better.. very good..

Hematology of infancy and childhood
For over 35 years Nathan and Oski's Hematology has been the precious companion for the pediatrician in pediatric hematology or the pediatrician on the ward looking for answers to thorny clinical questions. The present heavy book on my desk is the seventh edition. The oncology part of this book has been taken out in this edition and a new textbook (Oncology of infancy and childhood) created to deal with this vast field (see another review in this issue).


Personally I am very fond of history, because I believe it is important to know our past in order to understrand our present and future, so I am very delighted to again see the first chapter of this book with the history of pediatric hematology put in perspective by Wolf Zuelzer, who passed away in 1987 and updated by David Nathan. I am especially happy to see the reference to two of my mentors from my time at the University Hospital (Rigshospitalet) in Copenhagen, Svend Heinild (1907-1994) and Preben Plum (1906-2002), who as general pediatricians also contributed to the field of hematology with their research and treatment.


The chapter on the Thalassemias is also very profound and saw the discussion of the alpha Thallassemia with intellectual disability/mental retardation, which is rare but maybe an under-diagnosed entity.


All in all a book that should be in the library of every pediatric department around the world.


Professor Joav Merrick, MD, MMedSci, DMSc
Ministry of Social Affairs, National Institute of Child Health and Human Development, Jerusalem, Israel and Kentucky Children's Hospital, University of Kentucky, Lexington, United States.[...]